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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721982416db1a6b3e2411263350280a578ed583df487dc021e6b51b39bfc124c' 
  AND token = '2nHQ0Bi2ZXoaVsTDnIzwRc8TZNZQqim0wqj7FsbpD94=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

Explain
id	select_type	table	type	possible_keys	key	key_len	ref	rows	Extra
1	SIMPLE								Impossible WHERE noticed after reading const tables