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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b2e08d0b3b11575e2836b01c2e50893b0449c48c97d900b450bdc22b176243e' 
  AND token = 'hOFZQSn0Jw7ahWN9PDgnp4whQUIKzzFR0t9gTg3Ko4s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

Explain
id	select_type	table	type	possible_keys	key	key_len	ref	rows	Extra
1	SIMPLE								Impossible WHERE noticed after reading const tables