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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e80bbbbd7753bd1265980a3aed5ce57b431d5558903e991bb10d45579386729' 
  AND token = 'IRY9dmJJzyqRoPtzNbNvwNV5kJ2XpVP80SXN0cSw15w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

Explain
id	select_type	table	type	possible_keys	key	key_len	ref	rows	Extra
1	SIMPLE								Impossible WHERE noticed after reading const tables