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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1fca72197418c0081c66a7a7cd1113425dea54e82e36d7129d9f10563427e21f' 
  AND token = 'E2CzqUwnTUgtkbUIxqd2jJx8MUlSVcQsM2l3HXKd2q4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

Explain
id	select_type	table	type	possible_keys	key	key_len	ref	rows	Extra
1	SIMPLE								Impossible WHERE noticed after reading const tables